Endocrine Abstracts

Osteoporotic fractures are the main clinical manifestations of skeletal fragility and are associated with decreased survival and impaired quality of life in the general population. At the beginning of COVID-19 spread in Europe, despite several studies investigated COVID-19 clinical characteristics, no data were reported on the prevalence of vertebral fractures (VFs) in patients affected and disease impact on osteoporotic patients. We performed a retrospective study at San Raff...

Several reports of Graves’ disease (GD) onset after COVID-19 vaccination were recently published. The mechanism underlying GD occurrence in these cases could be related to the autoimmune syndrome induced by adjuvants (ASIA), a condition triggered by several vaccine adjuvants and excipients leading to dysfunctional immune response causing different conditions and endocrinopathies in genetically predisposed subjects. In Italy, population campaign for COVID-19 vaccination st...

Low vitamin D levels were consistently reported as a risk factor for worse outcomes in hospitalized COVID-19 patients. Emerging evidences suggest that in 50–70% of COVID-19 survivors several post-COVID symptoms can be observed up to 3 months after acute-disease, representing a novel clinical condition defined Long-COVID syndrome. To date, the predisposing factors for this syndrome are still poorly understood. We retrospectively aimed at evaluating the influence of 25(OH) ...

SARS-CoV-2 has rapidly spread from China throughout the world leading to a pandemic. COVID-19 can be severe enough to cause hospitalization and death. Many patients with endocrine disorders share many of the recognized risk factors for severe disease and have potential additional risks due to corticosteroid replacement therapy or alteration in blood electrolytes. We here report three cases of COVID-19 in patients with post-surgical hypopituitarism and documented hypocortisolem...

Coronavirus disease 2019 (COVID-19), is a primarily respiratory infection which can lead to severe syndrome needing hospitalization and assisted ventilation with high lethality. In a recent meta-analysis of 33 RCTs increased risk of severe infections on treatment with Denosumab, widely used for treatment of osteoporosis, was found specifically for ear, nose, and throat. In fact, by inhibiting the receptor activator of nuclear factor κ-Β ligand, denosumab acts as an i...

Morphometric-Vertebral Fractures (VFs), which were widely demonstrated to reduce overall-survival and respiratory function in the general population, have been recently reported to be highly prevalent in COVID-19 patients. Emerging data show negative respiratory sequelae at long-term follow-up in COVID-19 survivors. The aim of this study is to evaluate the VFs influence on respiratory function of COVID-19 survivors. We included COVID-19 patients admitted at San Raffaele-Hospit...

Medullary thyroid cancer (MTC) is a rare malignancy of the thyroid gland. MTCs originate from thyroid-C cells and account for 2-4% of all thyroid neoplasms. Originating from thyroid-C cells, the main secretory product of MTCs is calcitonin, used as sensitive and specific MTC-biomarker. Calcitonin is a hormone known to participate in calcium-bone metabolism suppressing bone-resorption by inhibiting the activity of osteoclasts, and inhibiting the kidney reabsorption of calcium a...

Introduction: Recent studies showed that morphometric vertebral fractures (VF) are an early and frequent complication in patients (pts) withhyperfunctioning pituitary adenomas and hypopituitarism (independently from the etiology). GH excess or severe deficiency play a negative key role on bone health in this clinical setting. Disease control or adequate replacement therapies still remain a cornerstone for the clinician to reduce the burden of osteo-metabolic complications. To ...

Coronavirus disease 2019 (COVID-19), may lead to a severe acute respiratory syndrome requiring hospitalization and assisted ventilation with high lethality. Replication of SARS-CoV, MERS-CoV and Ebolavirus is calcium-dependent and hypocalcemia has been frequently reported in all these infections. Despite already many studies reporting on clinical and laboratory presentation of COVID-19 patients, including inflammatory and organ injury biomarkers, only one case report has so fa...